PRP vs PRF: What's the Difference and Which Treatment Is Right for You?

If you're exploring natural alternatives to fillers and Botox, you've likely encountered PRP (Platelet-Rich Plasma) and PRF (Platelet-Rich Fibrin)—two of the most effective regenerative treatments for skin rejuvenation and hair restoration.

Both treatments harness your body's natural healing powers to stimulate collagen production, improve skin texture, and restore a youthful glow. But what's the difference between them, and which one is right for you?

At MAKI Med Spa & Wellness, we specialize in both PRP facial rejuvenation and PRF facial rejuvenation, helping clients achieve natural, long-lasting results that enhance their beauty from within.

What Is PRP (Platelet-Rich Plasma)?

PRP is a regenerative treatment that uses your own blood to promote healing and tissue regeneration. Here's what it does:

• Stimulates collagen and elastin production
• Improves skin tone, texture, and firmness
• Reduces fine lines and wrinkles
• Enhances overall skin radiance
• Treats hair loss and thinning

During a PRP treatment, a small amount of blood is drawn and processed in a centrifuge to concentrate the platelets. These platelets contain powerful growth factors that trigger your skin's natural repair mechanisms when injected back into targeted areas.

What Is PRF (Platelet-Rich Fibrin)?

PRF is the next generation of PRP technology, offering enhanced and longer-lasting results. The key differences include:

• Higher concentration of growth factors – PRF contains more platelets, white blood cells, and stem cells than PRP
• No additives – PRF is 100% natural with no anticoagulants or additives
• Slower, sustained release – Growth factors are released gradually over 7-10 days, providing extended healing benefits
• Richer fibrin matrix – Creates a natural scaffold that supports tissue regeneration

PRF is considered a more advanced treatment because it captures a broader range of healing components from your blood, resulting in more comprehensive rejuvenation.

PRP vs PRF: Key Differences

While both treatments use your blood to promote healing, here's how they compare:

Processing Method

• PRP uses higher-speed centrifugation with anticoagulants
• PRF uses low-speed centrifugation without additives, preserving more beneficial cells

Growth Factor Release

• PRP releases growth factors quickly over 1-2 days
• PRF releases growth factors slowly over 7-10 days for prolonged effects

Composition

• PRP contains concentrated platelets
• PRF contains platelets, white blood cells, stem cells, and fibrin

Results Timeline

• PRP shows results in 2-4 weeks, lasting 6-9 months
• PRF shows results in 3-6 weeks, lasting 9-12 months or longer

Ideal For

• PRP: Quicker results, skin texture improvement, hair restoration
• PRF: Deeper rejuvenation, volume restoration, long-term anti-aging

What to Expect During Treatment

At MAKI Med Spa & Wellness, both PRP and PRF treatments follow a similar process:

• Consultation – We assess your skin concerns, discuss your goals, and determine which treatment is best for you
• Blood Draw – A small amount of blood is drawn (similar to routine lab work)
• Processing – Your blood is centrifuged to isolate the platelet-rich concentrate
• Injection or Microneedling – The PRP or PRF is injected into targeted areas or combined with microneedling for enhanced absorption
• Post-Care Instructions – You'll receive guidance to maximize your results

Most clients experience minimal downtime, with mild redness or swelling that resolves within 24-48 hours. You can return to normal activities immediately after treatment.

How Long Do Results Last?

• PRP: Results typically last 6-9 months with optimal outcomes after 2-3 sessions
• PRF: Results can last 9-12 months or longer, with visible improvement after 2-3 treatments
• Both treatments work progressively—collagen production continues for several months after your session
• Maintenance sessions every 6-12 months help sustain your results

Which Treatment Is Right for You?

Choose PRP if:

• You want a proven, effective treatment at a lower cost
• Your primary concerns are fine lines, dullness, or hair loss
• You prefer quicker initial results
• You're new to regenerative aesthetics

Choose PRF if:

• You want the most advanced regenerative treatment available
• You're addressing deeper signs of aging or volume loss
• You prefer longer-lasting results with fewer maintenance sessions
• You want a 100% natural treatment with no additives

Not sure which is right for you? Our expert team at MAKI Med Spa will evaluate your skin and recommend the best treatment plan during your consultation.

Can PRP and PRF Be Combined With Other Treatments?

Absolutely! Both PRP and PRF can be enhanced when combined with:

• Microneedling – Increases absorption and collagen stimulation
• Exosome therapy – Amplifies cellular regeneration
• Sculptra – Boosts volume and long-term collagen production
• Dermal fillers – Provides immediate volume while PRP/PRF works gradually

Combining treatments can deliver comprehensive facial rejuvenation with both immediate and progressive results.

Safety and Side Effects

Both PRP and PRF are FDA-cleared and extremely safe since they use your own blood, eliminating the risk of allergic reactions or rejection. Side effects are minimal and may include:

• Mild redness or swelling (1-2 days)
• Minor bruising at injection sites
• Temporary tenderness

At MAKI Med Spa, we follow strict protocols to ensure your safety and comfort throughout the process.

Why Choose MAKI Med Spa & Wellness for PRP and PRF

• Advanced Regenerative Expertise – Specialized training in PRP and PRF techniques
• Personalized Treatment Plans – Customized to your unique skin goals
• Natural, Long-Lasting Results – Harness your body's healing power for authentic rejuvenation
• Comprehensive Aesthetic Care – From injectables to body contouring, we offer complete aesthetic solutions

Your skin deserves the best—safe, professional regenerative treatments that deliver real, lasting results.

Book Your PRP or PRF Consultation

Ready to experience the transformative power of regenerative aesthetics? Schedule a consultation at MAKI Med Spa in Winter Springs, FL today. Our expert team will help you choose between PRP and PRF and create a treatment plan designed specifically for you.

Whether you're looking to smooth fine lines, restore volume, or achieve an all-over glow, we're here to help you look and feel your absolute best.